Elevated Maternal Serum Alpha-Fetoprotein (MSAFP)

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During a second trimester serum screen for fetal spina bifida, a patient may have an elevated maternal serum Alpha-Fetoprotein (AFP, or MSAFP) level. Elevated MSAFP is associated with structural fetal anomalies, including neural tube defects, abdominal wall defects, and duodenal atresia. With targeted ultrasounds, abnormalities of the spine, brain, or abdominal wall should be apparent.

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